Dr du Toit's Pain Expeller

S0 Reg. No.: B/2.8/977, Dr du Toit's PAIN EXPELLER Tablets. Each tablet contains 300 mg Aspirin. Class: A2.8 Analgesic combinations. Applicant: iPharma (Pty) Ltd. 124 Elevation Avenue, Randjesfontein, Midrand, 1683, South Africa
Ph +27 (0)11 314 2366 Fax +27 (0)86 600 6315 info@ipharma.co.za Co. No.: 2010/000192/07 Marketed by Biotech Laboratories (Pty) Ltd. Co.No.: 1990/007220/07. Advert code: A0030/10/18 DOP: OCT2018

References

Walker J, Hutchison P1, Ge J, et al. Aspirin: 120 years of innovation. A report from the 2017 Scientific Conference of the International Aspirin Foundation, 14 September 2017, Charité, Berlin. Ecancermedicalscience. 2018;12:813.
Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic Therapy for Acute Pain. Am Fam Physician 2013;87(11):766-772.
DeNoon DJ. The 10 Most Important Drugs. WebMD [online]. Published 30/08/2004. Accessed 27/07/2018. Available at: https://www.webmd.com/genital-herpes/features/10-most-important-drugs#1.
Rogers K. 7 Drugs that Changed the World. Encyclopaedia Britannica [online]. Accessed 27/07/2018. Available at: https://www.britannica.com/list/7-drugs-that-changed-the-world Encyclopedia Britannica's The Greatest Inventions of All Times. Accessed 27/07/2018. Available at: https://ssthirdgrade.wikispaces.com/file/view/Greatest+Inventions+of+A ll+TimesEncyclopedia+Britannica.pdf
Goldberg DR. Aspirin: Turn-of-the-Century Miracle Drug. Science History Institute [online]. Published 2009. Accessed 27/07/2018. Available at: https://www.sciencehistory.org/distillations/magazine/aspirin-turn-of-the-century-miracle-drug
Dr Du Toit's PAIN EXPELLER Tablets approved package insert; 08/11/1984.
Blondell RD, Azadfard M, Wisniewski AM. Pharmacologic Therapy for Acute Pain. Am Fam Physician 2013;87(11):766-772

Abbreviated Package Insert

For full prescribing information refer to the package insert approved by the medicines regulatory authority

SCHEDULING STATUS: S0 PROPRIETARY NAME (AND DOSAGE FORM): Dr Du Toit's Pain Expeller Tablets. COMPOSITION: Each tablet contains Aspirin 300 mg. PHARMACOLOGICAL CLASSIFICATION: A 2.7 Antipyretic and/or anti-inflammatory analgesics. PHARMACOLOGICAL ACTION: They have analgesic, anti-inflammatory and anti-pyretic actions. They inhibit the biosynthesis of prostaglandins. INDICATIONS: Effective for the relief of pain of moderate intensity. DOSAGE AND DIRECTIONS FOR USE: ADULTS: One or two tablets three times a day with water. WARNINGS: Do not use continuously for longer than ten days without consulting your doctor. Not for children under 12 years of age. SIDE EFFECTS AND SPECIAL PRECAUTIONS: Dizziness or irritation of the gastric mucosa and resultant dyspepsia, haematemesis, and malaena may occur in some cases. Some persons, especially asthmatics, exhibit notable sensitivity to aspirin which may include skin eruptions, paroxysmal bronchospasm and dyspnoea. It should be administered with caution to patients with renal impaired functions, dyspepsia, anaemia and dehydrated patients. Aspirin may enhance the activity of coumarin anticoagulants and oral anti-diabetic preparations and sulphonamides. Aspirin diminishes the effects of anti-gout preparations, such as probenecid and sulphinpyrazone. Barbiturates and other sedatives may mask the respiratory symptoms of aspirin overdose and have been reported to enhance its toxicity. Prolonged use of high doses may lead to anaemia, blood dyscrasias, gastro-intestinal haemorrhage, peptic ulceration and renal papillary necrosis. The use of aspirin in the first trimester of pregnancy is not advised.